Holding(s) in Company

RENOVO GROUP PLC (“the Company”) Holding in Company The Company has received notification that, as at close of business on 7 December 2006, the Goldman Sachs Group, Inc.

RENOVO GROUP PLC (“the Company”) Holding in Company The Company has received notification that, as at close of business on 7 December 2006, the Goldman Sachs Group, Inc. (GS Inc) was interested, by attribution only, in 5,552,775 Renovo ordinary shares. Of these 5,552,775 shares: • The interest in 1,307,335 shares arose from the interest held by Goldman Sachs & Co., a wholly-owned direct subsidiary of GS Inc, acting as a custodian for its customers. • The interest in 4,245,440 shares arose from a beneficial interest held by Goldman Sachs International, a wholly-owned indirect subsidiary of GS Inc. Contact Renovo Group plc – Simon Bielecki 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 19 December 2006 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below

RENOVO GROUP PLC (“the Company”) 19 December 2006 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification HealthCap IV Bis, L.P. HealthCap IV, L.P. HealthCap IV IV, KB OFCO Club IV TOTAL Number of ordinary shares TOTAL Ownership Percentage
19 December 2006 8,099,875 11,209,516 817,987 306,631 20,434,009 11.53%
Change in Holding since last notification -839,260 -1,161,463 -84,755 -31,771 -2,117,249

For further information please contact Renovo Group plc – Simon Bielecki, Head of Communications 0161 606 7328

2006 Annual Report

RENOVO GROUP PLC Copies of the 2006 Annual Report, notice of Annual General Meeting and proxy form have been submitted and will shortly be available for inspection at the UK Listing Authority's do

RENOVO GROUP PLC Copies of the 2006 Annual Report, notice of Annual General Meeting and proxy form have been submitted and will shortly be available for inspection at the UK Listing Authority's document viewing facility situated at the Financial Services Authority, 25 The North Colonnade, Canary Wharf, London E14 5HS. For further information please contact: Simon Bielecki, Head of Communications +44 (0) 161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 22 January 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below

RENOVO GROUP PLC (“the Company”) 22 January 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification HealthCap IV Bis, L.P. HealthCap IV, L.P. HealthCap IV IV, KB OFCO Club IV TOTAL Number of ordinary shares TOTAL Ownership Percentage
22 January 2007 7,657,621 10,597,474 773,325 289,889 19,318,309 10.90%
Change in Holding since last notification -79,278 -109,715 -8,006 -3,001 -200,000

For further information please contact Renovo Group plc – Simon Bielecki, Head of Communications 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 25 January 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below

RENOVO GROUP PLC (“the Company”) 25 January 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification HealthCap IV Bis, L.P. HealthCap IV, L.P. HealthCap IV IV, KB OFCO Club IV TOTAL Number of ordinary shares TOTAL Ownership Percentage
25 January 2007 6,864,837 9,500,331 693,264 259,877 17,318,309 9.77%
Change in Holding since last notification -792,784 -1,097,143 -80,061 -30,012 -2,000,000

For further information please contact Renovo Group plc – Simon Bielecki, Head of Communications 0161 606 7328

Holding(s) in Company

Holding in Company

Holding in Company

Renovo Group Plc has received notification from The Goldman Sachs Group, Inc (“GS Inc”) that they no longer have a notifiable interest in shares in the Company. 

Contacts

Renovo Group Plc – Simon Bielecki 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 7 February 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below

RENOVO GROUP PLC (“the Company”) 7 February 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification HealthCap IV Bis, L.P. HealthCap IV, L.P. HealthCap IV IV, KB OFCO Club IV TOTAL Number of ordinary shares TOTAL Ownership Percentage
7 February 2007 6,290,069 8,704,903 635,219 238,118 15,868,309 8.96%
Change in Holding since last notification -118,917 -164,571 -12,010 -4,502 -300,000

For further information please contact Renovo Group plc – Simon Bielecki, Head of Communications 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 8th February 2007 Holding in Company The Company has received notification from JP Morgan Partners, LLC ("JPMP")of 1221 Avenue of the Americas, New York, NY, Un

RENOVO GROUP PLC (“the Company”) 8th February 2007 Holding in Company The Company has received notification from JP Morgan Partners, LLC ("JPMP")of 1221 Avenue of the Americas, New York, NY, United States that JPMP has decreased its material interest in the share capital of Renovo Group plc to 4.50%. Details are as follows: Number of shares sold: 2,661,474(1.50%) Total number of shares held by JP Morgan Partners, LLC: 7,984,420 (4.50%). Contacts Renovo Group plc – Simon Bielecki, Head of Communications: 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 16 February 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below

RENOVO GROUP PLC (“the Company”) 16 February 2007 Holding in Company The Company has received notification from HealthCap IV GP SA on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification HealthCap IV Bis, L.P. HealthCap IV, L.P. HealthCap IV IV, KB OFCO Club IV TOTAL Number of ordinary shares TOTAL Ownership Percentage
16 February 2007 5,287,198 7,317,017 533,941 200,153 13,338,309 7.53%
Change in Holding since last notification -396,391 -548,572 -40,031 -15,006 -1,000,000

For further information please contact Renovo Group plc – Simon Bielecki, Head of Communications 0161 606 7328

Holding(s) in Company

RENOVO GROUP PLC (“the Company”) 20 February 2007 Holding in Company The Company has received notification from Atlas Venture on the date indicated below that the legal entities listed below are

RENOVO GROUP PLC (“the Company”) 20 February 2007 Holding in Company The Company has received notification from Atlas Venture on the date indicated below that the legal entities listed below are interested in ordinary shares of 10p each of the Company’s issued share capital in the amounts listed below.

Date of Notification Atlas Venture Fund V, L.P. Atlas Venture Fund V-A, C.V. Atlas Venture Fund V-A, L.P. TOTAL Number of ordinary shares TOTAL Ownership Percentage
20 February 2007 16,252,039 4,038,016 270,075 20,560,130 11.60%
Change in Holding since last notification -1,688,659 -419,565 -28,062

For further information please contact Renovo Group plc – Rob Cridland, Executive Director, Finance and Business Development & Company Secretary. Tel +44 (0) 161 606 7332

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